The heavy-handed Brazilian knocked out former champ Cain Velasquez in just over a minute this past November on the UFC's inaugural FOX show to capture the belt, but has been sidelined since rehabbing a knee injury. Dos Santos is now on deck to attempt his first title defense against former Strikeforce heavyweight kingpin Alistair Overeem.
The two are to meet in the main event of the all-heavyweight UFC 146 fight card this May and dos Santos is confident that the title won't be changing hands on that night.
"My dream was to become the champion," dos Santos said. "The minute Dana strapped that belt around my waist, my dream got bigger. I'm not here to be a one or two-defense champion; I'm here to stay. On May 26, there's going to be a heavyweight striking war and someone is getting knocked out."
UFC 146 is expected to take place at the MGM Grand Garden Arena in Las Vegas, Nevada and will feature five high-level heavyweight bouts on the main card.
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