TRPM7 protein key to breast cancer metastasis in animal models

Public release date: 7-Aug-2012
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Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

PHILADELPHIA The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Cancer Research.

"The most important discovery that we report in this paper is that TRPM7 is required for metastasis, at least in a xenograft model of breast cancer metastasis," said Frank van Leeuwen, Ph.D., assistant professor at the Radbound University Medical Center in Nijmegen, the Netherlands. "While this fundamental biological finding will not have an immediate impact on patient care, we believe that it opens the door to a previously under-explored area of cancer therapeutics.

"TRPM7 functions as a cation channel. As such, it is in a class of proteins that is already therapeutically targeted to treat diseases; for example, cation channel blockers are used to treat several heart conditions. Given that cation channels are druggable, our data provide clear rationale for probing whether drugs that target this class of proteins could block metastasis."

Central to tumor metastasis are changes in the capacity of tumor cells to adhere to other cells and tissue at the original tumor site and changes in their ability to migrate. As TRPM7 was known to be involved in regulating cell adhesion and migration, van Leeuwen and his colleagues, including researchers at The Netherlands Cancer Institute in Amsterdam, set out to investigate whether TRMP7 had a role in cancer cell metastasis.

They evaluated whether the level of expression of the TRPM7 gene correlated with breast cancer progression. In primary breast tumors removed at diagnosis from a cohort of 368 women, high levels of expression from the TRPM7 gene were associated with significantly shorter times to both recurrence of disease and occurrence of distant metastases. This association was validated in an independent cohort of 144 breast cancer patients.

"We were able to show that high levels of TRPM7 expression independently predicted poor patient outcome in these two cohorts of women," said van Leeuwen. "Whether this is useful for forecasting patient prognosis awaits further validation. Moreover, it has become increasingly clear that it is not possible to stratify breast cancer patients into prognostically meaningful groups based on the level of expression of a single gene. TRPM7 would, therefore, need to be part of a panel of markers predictive of metastasis."

Having established a clinically relevant link between TRPM7 levels and metastatic disease in breast cancer patients, van Leeuwen and his colleagues examined the underlying molecular mechanisms using in vitro and in vivo assays.

The results indicated that knocking down TRPM7 expression in invasive human breast cancer cells impaired their ability to migrate in vitro and their metastatic potential when transferred into mice. Further analysis pinned down molecular and cellular reasons for these observations.

"Our working hypothesis is that TRPM7 has a key role in the cross-talk that goes on between breast cancer cells and their environment," van Leeuwen said. "Breast cancer cells are very sensitive to environmental cues. We think, but have no formal proof as yet, that TRPM7 channels are sensors that enable breast cancer cells to perceive changes in their environment."

###

The work was supported by grants from KWF Kankerbestrijding (Dutch Cancer Society).

Follow the AACR on Twitter: @aacr #aacr

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the AACR

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

For more information about the AACR, visit www.AACR.org.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 7-Aug-2012
[ | E-mail | Share ]

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

PHILADELPHIA The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Cancer Research.

"The most important discovery that we report in this paper is that TRPM7 is required for metastasis, at least in a xenograft model of breast cancer metastasis," said Frank van Leeuwen, Ph.D., assistant professor at the Radbound University Medical Center in Nijmegen, the Netherlands. "While this fundamental biological finding will not have an immediate impact on patient care, we believe that it opens the door to a previously under-explored area of cancer therapeutics.

"TRPM7 functions as a cation channel. As such, it is in a class of proteins that is already therapeutically targeted to treat diseases; for example, cation channel blockers are used to treat several heart conditions. Given that cation channels are druggable, our data provide clear rationale for probing whether drugs that target this class of proteins could block metastasis."

Central to tumor metastasis are changes in the capacity of tumor cells to adhere to other cells and tissue at the original tumor site and changes in their ability to migrate. As TRPM7 was known to be involved in regulating cell adhesion and migration, van Leeuwen and his colleagues, including researchers at The Netherlands Cancer Institute in Amsterdam, set out to investigate whether TRMP7 had a role in cancer cell metastasis.

They evaluated whether the level of expression of the TRPM7 gene correlated with breast cancer progression. In primary breast tumors removed at diagnosis from a cohort of 368 women, high levels of expression from the TRPM7 gene were associated with significantly shorter times to both recurrence of disease and occurrence of distant metastases. This association was validated in an independent cohort of 144 breast cancer patients.

"We were able to show that high levels of TRPM7 expression independently predicted poor patient outcome in these two cohorts of women," said van Leeuwen. "Whether this is useful for forecasting patient prognosis awaits further validation. Moreover, it has become increasingly clear that it is not possible to stratify breast cancer patients into prognostically meaningful groups based on the level of expression of a single gene. TRPM7 would, therefore, need to be part of a panel of markers predictive of metastasis."

Having established a clinically relevant link between TRPM7 levels and metastatic disease in breast cancer patients, van Leeuwen and his colleagues examined the underlying molecular mechanisms using in vitro and in vivo assays.

The results indicated that knocking down TRPM7 expression in invasive human breast cancer cells impaired their ability to migrate in vitro and their metastatic potential when transferred into mice. Further analysis pinned down molecular and cellular reasons for these observations.

"Our working hypothesis is that TRPM7 has a key role in the cross-talk that goes on between breast cancer cells and their environment," van Leeuwen said. "Breast cancer cells are very sensitive to environmental cues. We think, but have no formal proof as yet, that TRPM7 channels are sensors that enable breast cancer cells to perceive changes in their environment."

###

The work was supported by grants from KWF Kankerbestrijding (Dutch Cancer Society).

Follow the AACR on Twitter: @aacr #aacr

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the AACR

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

For more information about the AACR, visit www.AACR.org.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-08/aafc-tpk073112.php

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YaleNews | Yale study reveals new family tree for ray-finned fish

The most common lineages of fish found today in oceans, lakes, and rivers evolved about the same time as mammals and birds, a new Yale University-led study shows.

The comparative genetic analysis of more than 200 fish species, reported the week of Aug. 6 in the Proceedings of the National Academy of Sciences, gave an earlier than expected evolutionary birthday to well-known teleost ? or ray-finned ? fish such as salmon, bass, or tuna.

The analysis also shows that the very earliest lineages of living teleost fish were eels and bonefishes, not tropical freshwater bonytongue fish as some scientists had proposed.

?Half of all animals that have backbones are ray-finned fish, but we know little about their evolutionary history in contrast to other vertebrate lineages like frogs, lizards, birds, and mammals,? said Thomas Near of the Department of Ecology and Evolutionary Biology at Yale and lead author of the paper. ?Fish are usually viewed as primitive in origin, but we are learning that most of the familiar living lineages of fish arose more recently ? during what we might call the Second Age of Fishes.?

The Devonian period, 415 to 355 million years ago, is known as the Age of Fishes and saw the appearance of many types of fish such as bony fishes, sharks, skates, and rays, as well? lineages known only from the fossil record. The living lineages of teleost fish ? the major group of ray-finned fish ? were thought to have appeared some 150 million years ago. The Yale study suggests the evolutionary age of living teleosts may be closer to 300 million years old.

However, the analysis shows the great majority of teleost lineages found today appeared much later ? in the Cretaceous through the Paleocene, some 120 to 60 million years ago, along with the first mammals and birds. Near and his team are investigating whether the extinction event some 65 million years ago that killed off the last of the dinosaurs also may have facilitated teleost fishes to radiate throughout the world?s oceans and rivers, just as it led to rapid expansion of mammalian and bird diversity.

?The new family tree of ray-finned fish comes close to completing the book on the evolutionary relationships of vertebrates,? Near said.

Other Yale authors on the study are Ron I. Eytan, Alex Dornburg, and Kristen L. Kuhn.

The team of researchers included scientists from the University of California-Davis, John Wilkes Honors College, The Field Museum of Natural History, and the University of Oxford, United Kingdom.

The study was funded by the Yale Peabody Museum of Natural History and the National Science Foundation.

Source: http://news.yale.edu/2012/08/06/yale-study-reveals-new-family-tree-ray-finned-fish

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When Looking At Fit, Even CFOs Want A Sense of Humor

Candidates and hiring companies have at least one thing in common: Both are looking for the perfect match.

Skills, knowledge, and experience are the tangibles to determine a functional fit within an organization. Aspects of values and personality may determine one?s ability to adapt to an organization?s culture. Recruiters, human resources professionals, and hiring managers understand the value of assessing a candidate?s potential cultural fit. Poor cultural fit is something that cannot be resolved with training.

Cultural fit goes beyond simply getting along with fellow workers. For example, according to an Accountempts survey, ?Nearly eight in 10 (79%) chief financial officers (CFOs) interviewed said an employee?s sense of humor is important for fitting into the company?s corporate culture.? That is important to the employer and the employee. If you are going to spend more than 40 hours per week working, you want to be with people with whom you can relate.

There are several methods that employers, recruiters, and candidates use to ensure a cultural match is made.

Job Posting

An employer can signal candidates by writing a detailed job posting including information about the company and its culture. The description will hopefully attract candidates of like mind and deter candidates with opposing values. Take a look at these sample postings ? Apple,?Kaiser Permanente,?Solutions IQ. Can you determine if you would be a cultural match?

R?sum?

Just as an employer communicates their values through the job posting, a candidate can share their values through the r?sum?.

Candidates should be careful not to go over the top. For example, r?sum?s should focus on skills, accomplishments, and knowledge. Through achievements employees can demonstrate values such as customer care, attention to quality, and on-time delivery of projects. Characteristics such as humor and honesty are not necessary to list on a r?sum?. A candidate can also show compassion through community and philanthropic roles.

Interviewing

Employers may ask questions to uncover a candidate?s work ethics, personal values, and work style. This may be achieved through situational questions in which the interviewer inquires about a choice a candidate may make or how they would solve a particular problem. To determine fit, often multiple team members will interview the candidate.

Testing

Some employers use psychometric tests to learn more about a candidate?s personality traits, and how they will interact with others in the company. According to Sanford Rose, ?It has been estimated that 30% of all companies have incorporated some sort of personality testing into their hiring process.?

Internet Search

Employers can gain insight into an employee?s personality by reviewing a candidate?s postings on social media sites. Candidates can learn about a company by searching online and especially reviewing the corporate website.

Job Shadowing

A trial day or even few hours is a great way to for the candidate and the hiring company to evaluate each other.

It is beneficial to the employer and the candidate to be forthright and honest throughout the job/candidate selection process. Any manipulation or false representation can result in a mismatch, which is a setback for the employer and the employee. With openness during the process, a perfect match can be found.

Debra Wheatman is a Certified Professional Resume Writer (CPRW) and Certified Professional Career Coach (CPCC). She is globally recognized as an expert in advanced career search techniques with more than 18 years' corporate human resource experience. Debra is a featured blogger on numerous sites and posts regularly on her own site. She has been featured on Fox Business News, WNYW with Brian Lehrer, and quoted in leading publications, including Forbes.com, The Washington Post, The New York Times, The Wall Street Journal, and CNBC. Debra may be reached at debra@careersdonewrite.com or you may visit her website at http://www.careersdonewrite.com.

Source: http://www.fordyceletter.com/2012/08/07/when-looking-at-fit-even-cfos-want-a-sense-of-humor/

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Thousands of fish die as Midwest streams heat up

In this July 26, 2012 photo, dead fish float in a drying pond near Rock Port, Mo. Multitudes of fish are dying in the Midwest as the sizzling summer dries up rivers and raises water temperatures in some spots to nearly 100 degrees. (AP Photo/Nati Harnik)

In this July 26, 2012 photo, dead fish float in a drying pond near Rock Port, Mo. Multitudes of fish are dying in the Midwest as the sizzling summer dries up rivers and raises water temperatures in some spots to nearly 100 degrees. (AP Photo/Nati Harnik)

In this July 26, 2012 photo, dead fish decompose in a drying pond near Rock Port, Mo. Multitudes of fish are dying in the Midwest as the sizzling summer dries up rivers and raises water temperatures in some spots to nearly 100 degrees. (AP Photo/Nati Harnik)

In this July 26, 2012 photo, dead fish float in a drying pond near Rock Port, Mo., as a turkey vulture paces the shore. Multitudes of fish are dying in the Midwest as the sizzling summer dries up rivers and raises water temperatures in some spots to nearly 100 degrees. (AP Photo/Nati Harnik)

LINCOLN, Neb. (AP) ? Thousands of fish are dying in the Midwest as the hot, dry summer dries up rivers and causes water temperatures to climb in some spots to nearly 100 degrees.

About 40,000 shovelnose sturgeon were killed in Iowa last week as water temperatures reached 97 degrees. Nebraska fishery officials said they've seen thousands of dead sturgeon, catfish, carp, and other species in the Lower Platte River, including the endangered pallid sturgeon. And biologists in Illinois said the hot weather has killed tens of thousands of large- and smallmouth bass and channel catfish and is threatening the population of the greater redhorse fish, a state-endangered species.

So many fish died in one Illinois lake that the carcasses clogged an intake screen near a power plant, lowering water levels to the point that the station had to shut down one of its generators.

"It's something I've never seen in my career, and I've been here for more than 17 years," said Mark Flammang, a fisheries biologist with the Iowa Department of Natural Resources. "I think what we're mainly dealing with here are the extremely low flows and this unparalleled heat."

The fish are victims of one of the driest and warmest summers in history. The federal U.S. Drought Monitor shows nearly two-thirds of the lower 48 states are experiencing some form of drought, and the Department of Agriculture has declared more than half of the nation's counties ? nearly 1,600 in 32 states ? as natural disaster areas. More than 3,000 heat records were broken over the last month.

Iowa DNR officials said the sturgeon found dead in the Des Moines River were worth nearly $10 million, a high value based in part on their highly sought eggs, which are used for caviar. The fish are valued at more than $110 a pound.

Gavin Gibbons, a spokesman for the National Fisheries Institute, said the sturgeon kills don't appear to have reduced the supply enough to hurt regional caviar suppliers.

Flammang said weekend rain improved some of Iowa's rivers and lakes, but temperatures were rising again and straining a sturgeon population that develops health problems when water temperatures climb into the 80s.

"Those fish have been in these rivers for thousands of thousands of years, and they're accustomed to all sorts of weather conditions," he said. "But sometimes, you have conditions occur that are outside their realm of tolerance."

In Illinois, heat and lack of rain has dried up a large swath of Aux Sable Creek, the state's largest habitat for the endangered greater redhorse, a large bottom-feeding fish, said Dan Stephenson, a biologist with the Illinois Department of Natural Resources.

"We're talking hundreds of thousands (killed), maybe millions by now," Stephenson said. "If you're only talking about game fish, it's probably in the thousands. But for all fish, it's probably in the millions if you look statewide."

Stephenson said fish kills happen most summers in small private ponds and streams, but the hot weather this year has made the situation much worse.

"This year has been really, really bad ? disproportionately bad, compared to our other years," he said.

Stephenson said a large number of dead fish were sucked into an intake screen near Powerton Lake in central Illinois, lowering water levels and forcing a temporary shutdown at a nearby power plant. A spokesman for Edison International, which runs the coal-fired plant, said workers shut down one of its two generators for several hours two weeks ago because of extreme heat and low water levels at the lake, which is used for cooling.

In Nebraska, a stretch of the Platte River from Kearney in the central part of the state to Columbus in the east has gone dry and killed a "significant number" of sturgeon, catfish and minnows, said fisheries program manager Daryl Bauer. Bauer said the warm, shallow water has also killed an unknown number of endangered pallid sturgeon.

"It's a lot of miles of river, and a lot of fish," Bauer said. "Most of those fish are barely identifiable. In this heat, they decay really fast."

Bauer said a single dry year usually isn't enough to hurt the fish population. But he worries dry conditions in Nebraska could continue, repeating a stretch in the mid-2000s that weakened fish populations.

Kansas also has seen declining water levels that pulled younger, smaller game fish away from the vegetation-rich shore lines and forced them to cluster, making them easier targets for predators, said fisheries chief Doug Nygren of the Department of Wildlife, Parks and Tourism.

Nygren said he expects a drop in adult walleye populations in the state's shallower, wind-swept lakes in southern Kansas. But he said other species, such as large-mouth bass, can tolerate the heat and may multiply faster without competition from walleye.

"These last two years are the hottest we've ever seen," Nygren said. "That really can play a role in changing populations, shifting it in favor of some species over others. The walleye won't benefit from these high-water temperatures, but other species that are more tolerant may take advantage of their declining population."

Geno Adams, a fisheries program administrator in South Dakota, said there have been reports of isolated fish kills in its manmade lakes on the Missouri River and others in the eastern part of the state. But it's unclear how much of a role the heat played in the deaths.

One large batch of carp at Lewis and Clark Lake in the state's southeast corner had lesions, a sign they were suffering from a bacterial infection. Adams said the fish are more prone to sickness with low water levels and extreme heat. But he added that other fish habitat have seen a record number this year thanks to the 2011 floods.

"When we're in a drought, there's a struggle for water and it's going in all different directions," Adams said. "Keeping it in the reservoir for recreational fisheries is not at the top of the priority list."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-08-05-Drought-Dead%20Fish/id-d38a23b9ca1449378a004953cc397f57

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Foolproof security on Youm-e-Ali | Pakistan Today | Latest news ...

KARACHI?-?Sindh Inspector General of Police (IGP) Fayaz Ahmed Leghari on Sunday ordered the senior officers to ensure foolproof security especially on Youm-e-Ali to be observed on 21st of Ramazan ul Mubark.

According to an official statement, the IGP directed that while preparing the security plan/strategy, the role of the Crime Investigation Department (CID) and of other intelligence agencies must be taken into account to make the security arrangements more effective.

He directed that the police officers and the police staff deployed on security duty must be properly equipped with modern arms, and that they should be duly briefed about their presence at certain points and the security task given to them.

He asked that every practical security measure be taken including using the services of bomb disposal squad to provide security to the rallies on Youm-e-Ali.

He also ordered that check posts be set up at entry points of the main cities and important places of the province and snap checking be ensured besides deployment of police personnel at mosques and imam bargahs.

The IGP directed further that on the eve of Youm-e-Ali, a traffic diversion plan be made to ensure smooth traffic flow.

Security at SU campus to be tightened: The management of Sindh University has decided to further strengthen the security arrangements in order to provide a peaceful atmosphere for academic activities in the campus to the students.

The Vice Chancellor Dr Nazir A Mughal, who presided over a meeting on Saturday in this connection, discussed at length the security arrangements as well as deployment of security staff in and outside the campus.

The meeting was also attended by representatives of Police and Rangers who approved the new security plan with setting up of the security points near the Department of Microbiology and deployment of Police personnel in order to maintain law and order.

It was decided in the meeting that the installation of walk through gates at the main entrances of the hostels be ensured to avert any attempt of carrying arms and ammunition inside the hostels and also to install closed circuit cameras at the Faculty of Arts, Allama I.I. Qazi Central Library and Allama I.I Qazi roundabout to monitor the activities of students and outsiders in an effective manner.

They also decided to construct a wall at the point of road which came from Sindhi Adabi Board to foil the attempt of entry of unauthorized persons into the premises of university and to close all illegal entry points and construct a compound wall to secure vehicles in private parking.

Profiteers warned of action: Deputy Commissioner Larkana Abdul Aleem Lashari has warned the shopkeepers to display price lists at conspicuous places and items of daily use should be sold on the fixed rates.

Addressing a meeting on Saturday, he said that profiteering and hoarding would be checked throughout the district.

He also said that strict action would also be taken against those violating the official rate list.

He directed the assistant commissioners and Mukhtiarkars to check the prices of essential commodities and nobody should be allowed to hoard sugar and other essential commodities, he added.

He asked magistrates to take stern action against hoarders.

Source: http://www.pakistantoday.com.pk/2012/08/06/city/karachi/foolproof-security-on-youm-e-ali/

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Boise State football camp notebook: Broncos adjust to NCAA sanctions

Boise State?s incoming football recruits have traded couches for beds ? and become less comfortable.

The Broncos addressed the situation that led to their NCAA violations by creating a bridge program for new players, who live in dorms and take two classes while working out with the team during the summer.

It?s a grueling introduction to college football ? and one coach Chris Petersen still doesn?t like, but has accepted as a defense against rules violations.

?Happier, yes,? he said of his take on the second year of the program. ?Do I think it?s the best way? No.?

The Broncos got in trouble with the NCAA because incoming recruits were sleeping on couches and floors at the residences of their new teammates during voluntary summer workouts. Those are impermissible benefits. The penalties, announced in September 2011, included three fewer preseason practices in 2011 and 2012, less contact in spring ball for three years and the loss of nine scholarships. The scholarship total was ruled excessive by the NCAA appeals committee but hasn?t been reduced yet.

Petersen implemented the bridge program last year to avoid such problems. The players arrive together in June and can live in the dorms and be on scholarship because of their classes.

The days are long, with two classes every weekday, conditioning workouts and player-run practices. There?s study hall, too.

?It was a wake-up call, definitely,? said redshirt freshman defensive end Sam Ukwuachu, who participated in the program last year. ?We didn?t get done until late in the evening. It?d be a grind.?

Petersen tweaked the program this year. One change: The players were in class Monday-Friday instead of Monday-Thursday, which made shorter class periods.

Boise State and its recruits also were more prepared than last year, Petersen said.

?These guys handled it better,? he said.

The team leaders noticed that, too.

?This class is more focused,? senior cornerback Jamar Taylor said. ?They want to play. And they know if they come in and handle their business they?ll be OK.?

CAMP IMPRESSIONS

? Defensive tackle Mike Atkinson and wide receiver Mitch Burroughs, both seniors, showed up frequently in the Sunday morning veteran practice. Atkinson was in on two sacks, forcing a fumble, and Burroughs made one nifty catch along the sideline on a well-defended pass and broke free down the field for another grab.

? True freshman wide receiver Shane Williams-Rhodes (5-foot-7, 160 pounds) generated a buzz among the veterans watching the afternoon newcomers practice with two big plays, including one on which he juked a defender after a short catch and took off down the sideline. On National Signing Day, coach Chris Petersen said: ?The smallest guy on our roster might be the guy that excites everybody the most. I don?t like to put pressure on any guys, but coming in we haven?t had many guys who have made the plays he can make in high school.?

? Redshirt freshman tight end Holden Huff was Petersen?s camper of the day after making several catches. ?Holden is making plays for us out there, and we like playmakers,? Petersen told Broncosports.com.

SPOTLIGHT ON ? OL JAKE BROYLES

Junior Jake Broyles is right back where he was a year ago ? fighting for a starting job on the Broncos? offensive line.

He won the job at right guard in 2011 but injured the big toe on his left foot in the third game of the year. He missed the rest of the season and eased back into action in spring ball.

He?s 100 percent now and competing with senior Michael Ames, junior Spencer Gerke and senior Brenel Myers ? all of whom have starting experience ? for a spot on the line.

?It?s awesome,? Broyles said. ?We?re all huge competitors. We all want to be out there. We know at the end of the day the best guy?s going to get the job.?

Broyles was surprised to learn that his injury required such an extensive rehab. He figured a toe wouldn?t be that bad.

?It just happens, and (the season) is gone like that,? he said. ?It?s a little hard to deal with it. You realize you have a couple years left and you still have teammates that need your support.?

He tried to use the time wisely. He improved his upper-body strength, worked his healthy leg and evaluated his own game.

?Mostly my footwork needs to be a little more precise,? he said.

He also drew motivation from the setback.

?It puts everything in perspective of how this is what you wanted to do ever since you can remember,? Broyles said. ?It gives you a little bit more motivation that you want to be out there and stay healthy.?

MEANWHILE, AT FRESNO STATE ?

The Bulldogs? offensive linemen are getting fitter and leaner to survive in the fast-paced, no-huddle offense of new coach Tim DeRuyter, the Fresno Bee reports. One lineman, Cody Wichmann, has lost about 30 pounds.

?They look different walking onto the field,? offensive line coach Cameron Norcross told the Bee. ?They don?t waddle onto the field, they saunter. They have a swagger to them now because they know they?ve changed themselves.?

Chadd Cripe: 377-6398, Twitter: @IDS_BroncoBeat

Source: http://feedproxy.google.com/~r/IdahostatesmancomBSUFootball/~3/z3zth796a0U/boise-state-adjusts-to-ncaa-sanctions.html

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Pet dogs Are Keen To Make sure you, So Instruction Is Easy-to-use ...

Dog training can be a learning experience for the pet, but ghds you can also learn other essential things, too. This informative article can help you get the most from education your pet. You will find that your time and efforts put in instruction your pet dog could have positive aspects for the both of you, for many years.

Dog proof your home to avoid treasured assets from being your puppy?s favored chew toy. Eliminate products, for example shoes or boots, through the area that you keep the pet. Many dog merchants offer a bitter sampling squirt that you can use and also hardwearing . pup from nibbling on electric cords. Understand that most puppies will outgrow this point.

Your house is your domain. Your pet dog should start to see the atmosphere they live in as your territory. Stepping close to a being untruthful canine or not shifting your pet coming from a place you intend to use presents him the right of way. This must not be permitted. Dominance from the pack ghd straighteners means exercising your strength within a no-confrontational way however with organization take care of that it is your territory.

Be as generous with fondness since you are with self-control. So many individuals invest quite a lot of time screaming at their canine to quit undertaking stuff that they should not be undertaking and not plenty of time exhibiting their dog they really like them. Let him know he is loved and then he is certain to act much better.

Until your pet dog is well trained, training ought to be constant. In case you are uncertain that the pet follows any command which you give, coaching is not really done. Each connection along with your dog ought to be handled from your prominent, training standpoint. You should consistently teach ghds your dog that you are in control, much like an authentic package leader does.

Make sure your lawn is free of charge from burrowing wild pets to maintain your dog from digging. Some puppies, especially hunting varieties, will look when looking for prey. Getting gentle methods to clear your lawn of other creatures will help to quit this difficult behavior. Wilderness animals can be deterred or relocated in the interest of each your lawn as well as your dog.

When attemping to exercise your pet dog, avoid unintentionally strengthening bad behaviours. Which means that you must by no means prize your pet, with snacks or ghds attention, for undertaking anything you?re attempting to teach it of. As an example, don?t rub your dog?s head when they bounce up at you and when you are available in the doorway in the event you don?t want them to leap.

Use suitable advantages and punishments when instruction your puppy. For instance, several pet dogs react positively when recognized having a preferred treat forever conduct. As well, be aware that extreme punishment can backfire. Rather, use a consistent strengthen of tone of voice or control term to show in your dog whenever a habits is unacceptable.

As was stated previously, proper dog training can be quite a chance to learn for you and your dog. If you take ghd straighteners the recommendation in this article to coronary heart, you may make sure a bond between pet and oneself. This period will likely be spent well and make a companionship that can benefit the the two of you.

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Source: http://articlereference.net/business/pet-dogs-are-keen-to-make-sure-you-so-instruction-is-easy-to-use.html

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